ANTIDIABETIC ACTIVITY OF THE COMBINATION OF SEPAT RAWA FISH FLOUR (Trichopodus thricopterus) AND ETHANOL EXTRACT OF RAMANIA LEAVES (Bouea Macrophylla Griffith)
AKTIVITAS ANTIDIABETES KOMBINASI TEPUNG IKAN SEPAT RAWA (Trichopodus thricopterus) DAN EKSTRAK ETANOL DAUN RAMANIA (Bouea Macrophylla Griffith)
DOI:
https://doi.org/10.20414/spin.v6i1.9505Keywords:
Antidiabetic, Bouea macrophylla Griffith, Ramania, Sepat rawa fish, antidiabeticAbstract
Diabetes mellitus is a metabolic disease with impaired insulin secretion. Sepat Rawa fish has been proven to contain alpha-amino acids, which can increase insulin action by increasing energy in the cell metabolic cycle. Ramania leaves contain compounds for antidiabetic treatment, such as saponins and flavonoids. This study aims to find the best dose to increase the antidiabetic activity of the combination of sepat rawa fish meal and ethanol extract of ramania leaves. This research activity uses pre- and post-tests with a control group design. The 25 mice used were divided into 5 groups, namely group I: negative control (CMC Na 0.5%), group II: positive control (glibenclamide 3 mg/kgBW), group III: sepat Rawa fish meal dose of 300 mg/kg. KgBW, group IV: ramania leaf extract at a dose of 300 mg/kg BW, group V: a combination of fish meal 300 mg/KgBW and ethanol extract of ramania leaf 300mg/kg BW. Mice were induced by alloxan to experience hyperglycemia. Observations on the decrease in blood sugar levels of each test group were carried out on the 7th day after alloxan induction by taking sufficient blood from the tails of mice and measuring using glucose. Data was analyzed for variance (ANOVA) (p=0.05). The result is that a single group of Ramania extract with a dose of 300 mg/KgBB shows the best activity with a percent decrease in blood sugar levels by 28.438, a combination dose of 25.107 %, and a Sepat Rawa dose of 21,675%. The Third of them was not significantly different with positive control.
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Adawyah, R., Khotiffah, S. K., Wahyudinur., & Puspitasari, F. (2020). Pengaruh Lama Pemasakan Terhadap Kadar Protein, Lemak, Profil Asam Amino, Dan Asam Lemak Tepung Ikan Sepat Rawa (Trichogaster Trichopterus). JPHPI, 23: 286-294
Astuti, K. I., & Fitriyanti. (2020). Karakteristik Protein Ikan Sepat Rawa (Trichopodus thricopterus) Asal Kalimantan Selatan Yang Berpotensi Sebagai Antidiabetes. Jurnal Ilmiah Ibnu Sina. 5(1): 201-210.
Astuti, K. I., Fitriyanti., & Alista, S. (2023). Efektivitas Tonikum Tepung Ikan Sepat Rawa (Trichopodus thricopterus) Dengan Metode Rotarod Test. MPI (Media Pharmaceutica Indonesiana), 5 (2) : 172-177.
Chaidir, R., Wahyuni, A. S., & Furkhani, D. W. (2017). Hubungan Self Care Dengan Kualitas Hidup. Journal Endurance, 2(2): 132-144.
Chatterjee, S., Davies, M. J., Heller, S., Speight, J., Snoek, F. J., & Khunti, K. (2018). Diabetes Structured Self-Management Education Programmes: Anarrative Review And Current Innovations. Lancet Diabetes & Endocrinology,6(2): 130–142.
Endah, B. R., Fitriyanti., Astuti, K. I., & Vebruati. (2022). Anal?s?s Karakter?st?k Organolept?s Dan Kimia Tepung Ikan Sepat Rawa (Tr?chopodus tr?chopterus). Journal Borneo. 2(2) : 99-104.
Fatmawati & Mardiana. (2014). Analisa Tepung Ikan Gabus sebagai Sumber Protein. Octopus Jurnal Ilmu Perikanan. 3(1) 235-243.
Fiana, N. & Oktaria, D. (2016). Pengaruh Kandungan Saponin dalam Daging Buah Mahkota Dewa (Phaleria macrocarpa)terhadap Penurunan Kadar Glukosa Darah. Journal MAJORITY. 05 (04): 128
Fitriyanti., Karunita, I. A., & Noraida, R. (2021). Acute Toxicity Study of Sepat Rawa (Trichopodus trichopterus) Flour of South Kalimantan on The White Mice. International Conference on Health and Science. 1(1): 761-767.
Gumelar, B., Ekowati, R., Furqonni, A. R. (2017). Potensi Ekstrak Etanol Daun Sirsak (Annona muricata) sebagai Agen Terapi Hiperglikemia pada Mencit yang Diinduksi Aloksan. Bandung Meeting on Global Medicine & Health (BaMGMH), 1 (1).
Harapan., Jamil, K., Hayati, Z., & Muhammad, I., (2010), Peran Puasa Dalam Remodelling Sel Enteroendokrin Untuk Mencegah Diabetes Melitus Tipe 2. The Journal of The Indonesian Medical Student Association.1 (1).
Hidayaturrahmah., Santoso, H. B., & Nurlely. (2017). Profil Glukosa Darah Tikus Putih Setelah Pemberian Ekstrak Minyak Ikan Patin (Pangasius hypopthalmus) Sebagai Alternatif Antidiabetes. Jurnal Pharmascience. 4(2): 219-226.
Hossain, M. K., Dayem, A. A., Han, J., Saha, S. K.,Yang, G., Choi, H. Y., & Cho, S. (2016). Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 17: 256.
International Diabetes Federation (IDF) diabetes atlas eighth edition 2017. Brussel: International Diabetes Federation. Retrieved from https://diabetesatlas.org/. Diakses tanggal 10 November 2022.
Karnila, B. (2012). Daya hipoglikemik Protein teripang Pasir (Holothuria scabra J.) pada Tikus Percobaan. Disertasi. Institut Pertanian Bogor, Bogor.
Kumalasari, E., Santoso, Y., Rahmi, M. Y., Febrianty, D. R. (2019). Pengaruh Pemberian Ekstrak Etanol Daun Ramania (Bouea macrophylla Griffith) Terhadap Penurunan Kadar Gula Darah Mencit Putih (Mus muscullus) Yang Diinduksi Aloksan. Journal of Current Pharmaceutical Sciences. 2(2): 173-179
Prastari C., Yasni, S., & Nurilmata, M. (2017). Karakteristik Protein Ikan Gabus yang Berpotensi Sebagai Antihiperglikemik. JPHPI. 20(02): 413-423
Putra, W. P., Nopianti, R., & Herpandi. (2017). Kandungan Gizi dan Profil Asam Amino Tepung Ikan sepat Siam ( Trichiagaster pectoralis). Fishtech. 6(2): 174-185.
Putri, N. H. K., & Isfandiari, M. A. (2013). Hubungan Empat Pilar pengendalian DM Tipe 2 Dengan Rerata Kadar Gula Darah. Jurnal Berkala Epidemiologi. 1(2): 234-243
Rahman, A., Taufiqurrahman, I., & Edyson. (2017). Perbedaan Total Flavonoid Antara Metode Maserasi Dengan Sokletasi Pada Ekstrak Daun Ramania (Bouea macrophylla Griffith) Jurnal Kedokteran Gigi, 1(1).
Rudijanto, A., Yuwono, A., Shahab, A., Manaf, A., Pramono, B., Lindarto, D., ..., & Langi, Y.A. (2015). Konsensus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Di Indonesia. Pengurus Besar Perkumpulan Endokrinologi Indonesia (PB PERKENI), Jakarta.
Samsul, E., Soemardji, A. A., & Kusmardiyani, S. (2020). Aktivitas Antidiabetes Serbuk Semut Jepang (Tenebrio molitor Linn.) pada Mencit Swiss Webster Jantan yang Diinduksi Aloksan. JSK. 2(4): 298-302.
WHO (World Health Organization). 2013. Diabetes. http://www.who.int/ mediacentre /factsheets/fs312/en. html [1 November 2022]
Yuwen, L., Park, J., Wu, Y., Cui, J., Jia, N., Xi, N., & Wen, A. (2017). Identification Of AMPK Activator From Twelve Pure Compounds Isolated From Aralia Taibaiensis: Implication In Antihyperglycemic And Hypolipidemic Activities. Korean J Physiol Pharmacol. 21(3):279–86.
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